An improved route to 19-hydroxypregn-4-ene-3,20-dione and synthesis of its [19-2H2] analogue
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2225-2227
- https://doi.org/10.1039/p19830002225
Abstract
3β-Acetoxy-5-bromo-6β,19-epoxy-5α-pregnan-20-one is more reliably converted into 19-hydroxyprogesterone via reductive opening of the epoxide to give 3β-acetoxy-19-hydroxypregn-5-en-20-one than by a previously published procedure. 19-Hydroxyprogesterone has been converted into its [192-H2] analogue in good yield.Keywords
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