Intra-Articular Injection of Cortisone in the Treatment of Rheumatoid and Hypertrophic Arthritis

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Abstract
THE intra-articular use of cortisone in the treatment of rheumatoid and hypertrophic arthritis has not been investigated as widely as the use of hydrocortisone. In 1951 Duff and his co-workers1 found that intra-articular injection of cortisone reduced the number of white cells in the synovial fluid in cases of rheumatoid arthritis and improved the viscosity and quality of mucin. Similar effects of hydrocortisone were found to be more lasting. The investigators interpreted these findings as support for the belief that both cortisone and hydrocortisone act directly on connective tissue. Early clinical reports2 3 4 showed intra-articular injection of cortisone to have transient . . .