Onset of peak impairment after diazepam and after alcohol
- 30 September 1981
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 30 (4) , 534-538
- https://doi.org/10.1038/clpt.1981.199
Abstract
Single doses of diazepam induced peak impairment of performance in humans on cognitive and psychomotor tasks early (20 min after ingestion), when blood levels had reached < 2/3 of their eventual plateau. Alcohol did not have this effect. Early peak impairment and the acute tolerance that follows it contribute greatly to the lack of correlation between diazepam plasma level and performance impairment.This publication has 4 references indexed in Scilit:
- Rapid Gas Chromatographic Assay of Serum Diazepam, N-Desmethyldiazepam, and N-DesalkylflurazepamActa Pharmacologica et Toxicologica, 2009
- Use of simple tasks to test for impairment of complex skills by a sedativePsychopharmacology, 1981
- Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to drivingEuropean Journal of Clinical Pharmacology, 1978
- The Influence of Alcohol on Automobile Driving Ability. An Experimental Study for the Evaluation of Certain Medicological AspectsQuarterly Journal of Studies on Alcohol, 1958