Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography
- 1 September 1990
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 2 (3) , 215-224
- https://doi.org/10.1007/bf02257652
Abstract
Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.Keywords
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