Characterization of cefsulodin-resistant variants of Pseudomonas aeruginosa
- 1 February 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 9 (2) , 111-117
- https://doi.org/10.1093/jac/9.2.111
Abstract
Fifty clinical strains of Pseudomonas aeruginosa were grown in the presence of cefsulodin and 96% acquired resistance to the antibiotic after 8 serial passages. Cross-resistance was observed between cefsulodin, carbenicillin and ticarcillin and growth of the strains on carbenicillin also induced resistance to the other two antibiotics. The resistant progeny fell into two categories, the first included strains which were indistinguishable phenotypically from the original strain and the second group were atypical in some biochemical tests confirmatory for Ps. aeruginosa and were not typable by serology and phage-typing. Neither category reverted to cefsulodin susceptibility after repeated subcultures on antibiotic-free media over a period of 6 months.Keywords
This publication has 5 references indexed in Scilit:
- In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamasesAntimicrobial Agents and Chemotherapy, 1980
- Cefsulodin, a cephalosporin with specific antipseudomonal activity; in vitro studies of the drug alone and in combinationJournal of Antimicrobial Chemotherapy, 1979
- Characteristics of Pseudomonas aeruginosa in relation to laboratory-induced resistance to gentamicin.Journal of Clinical Pathology, 1979
- The identification of pseudomonads and related bacteria in a clinical laboratoryJournal of Medical Microbiology, 1978
- 2 SIMPLE MEDIA FOR THE DEMONSTRATION OF PYOCYANIN AND FLUORESCIN1954