O-DEPHENYLATION AND CONJUGATION WITH BENZOYLORNITHINE - NEW METABOLIC PATHWAYS FOR 3-PHENOXYBENZOIC ACID IN CHICKENS

  • 1 November 1988
    • journal article
    • research article
    • Vol. 16  (6) , 818-822
Abstract
Metabolism of [benzyl-14C]fluvalinate by chickens produces 3-phenoxybenzoic acid, which is further degraded by two new pathways. The first pathway involves O-dephenylation, not reported previously for related pyrethroids in birds or mammals. O-Dephenylation is a major metabolic route (12% of the applied 14C). In the second pathway, 2% of the applied dose is converted into four conjugates of benzoylornithine (two with 3-hydroxybenzoic and two with 3-phenoxybenzoic acids). The predominant conjugate with benzoylornithine is N2-(3-hydroxybenzoyl)-N5-benzoylornithine.

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