PI-loting membrane traffic
- 1 June 2004
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 6 (6) , 487-492
- https://doi.org/10.1038/ncb0604-487
Abstract
Phosphoinositides (PIs) undergo phosphorylation/dephosphorylation cycles through organelle-specific PI kinases and PI phosphatases that lead to distinct subcellular distributions of the individual PI species. Specific PIs control the correct timing and location of many trafficking events. Their ultimate mode of action is not always well defined, but it includes localized recruitment of transport machinery, allosteric regulation of PI-binding proteins and changes in the physical properties of the membrane.Keywords
This publication has 62 references indexed in Scilit:
- Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma MembraneJournal of Biological Chemistry, 2003
- PI3P signaling regulates receptor sorting but not transport in the endosomal pathwayThe Journal of cell biology, 2003
- ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosisThe Journal of cell biology, 2003
- Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the GolgiCell, 2003
- A cycle of Vam7p release from and PtdIns 3-P–dependent rebinding to the yeast vacuole is required for homotypic vacuole fusionThe Journal of cell biology, 2002
- Simultaneous Binding of PtdIns(4,5)P 2 and Clathrin by AP180 in the Nucleation of Clathrin Lattices on MembranesScience, 2001
- Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cellsThe EMBO Journal, 2000
- Specific Interaction of Golgi Coatomer Protein α-COP with Phosphatidylinositol 3,4,5-TrisphosphatePublished by Elsevier ,1998
- Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase ActivityJournal of Molecular Biology, 1996
- An essential role for a phospholipid transfer protein in yeast Golgi functionNature, 1990