Specific distribution of metabolic alterations in cerebral cortex following apomorphine administration

Publisher Website
Google Scholar
Abstract
The topographic distribution of dopaminergic receptors in the cerebral cortex closely parallels that of the dopaminergic innervation1–6. In the rat, dopaminergic axons which originate in the mesencephalon are confined to a few discrete regions of the neocortex—anterior cingulate cortex, entorhinal cortex, frontal cortex (particularly anteromedial and supragenual areas) and the transitional zone between the neocortex and the pyriform cortex1–4. Moreover, biochemical examinations of processes generally considered to be indicative of dopaminergic neurotransmission—neuronal uptake of labelled dopamine or dopamine-activation of adenylate cyclase activity5,6—have confirmed a highly restricted locus of action of dopaminergic systems in the cerebral cortex. We describe here data obtained using the 2-deoxyglucose technique7 in conjunction with conventional neuropharmacological techniques, suggesting that the influence of dopaminergic systems on cortical function extends beyond the known confines of the mesocortical dopaminergic system.