Evidence that the serological determinant of H–Y antigen is carbohydrate

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Abstract
H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with maleness among a variety of mammalian species. To characterize the molecular determinant responsible for H-Y-specific serological activity, H-Y-positive [murine] immunoabsorbent cells were 1st subjected to various treatments which alter protein or carbohydrate structure and then tested for their ability to absorb H-Y antisera. Apparently the serological determinant of H-Y antigen is carbohydrate.