Liposome‐Entrapped γ‐Aminobutyric Acid Inhibits Isoniazid‐Induced Epileptogenic Activity in Rats
- 1 April 1986
- Vol. 27 (2) , 98-102
- https://doi.org/10.1111/j.1528-1157.1986.tb03509.x
Abstract
Sprague-Dawley rats with interictal and ictal spike activity induced by intraperitoneally injected isoniazid (INH) were treated, 5 min before or 30 min later, with liposome-entrapped .gamma.-aminobutyric acid (GABA) (LEG) or GABA or phosphatidylserine. Crossover injections were given in random sequence and INH alone was also injected in every animal as a control. LEG inhibited either seizures or interictal spikes in both groups. No decrease of epileptogenic activity was seen after GABA or phosphatidylserine treatment alone. It is suggested that LEG could contribute to the reconstitution of the GABA pool decreased by INH.This publication has 12 references indexed in Scilit:
- Phosphatidylserine Enhancement of [3H]γ‐Aminobutyric Acid Uptake by Rat Whole Brain SynaptosomesJournal of Neurochemistry, 1982
- Liposome Disposition in Vivo II: Dose DependencyJournal of Pharmaceutical Sciences, 1982
- Regulation of gaba receptor binding to synaptic plasma membrane of rat cerebral cortex: The role of endogenous phospholipidsBrain Research, 1981
- THE CONVULSANT ACTION OF HYDRAZIDES AND REGIONAL CHANGES IN CEREBRAL γ‐AMINOBUTYRIC ACID AND PYRIDOXAL PHOSPHATE CONCENTRATIONSJournal of Neurochemistry, 1979
- STABILITY OF SYNAPTOSOMAL GABA LEVELS AND THEIR USE IN DETERMINING THE IN VIVO EFFECTS OF DRUGS: CONVULSANT AGENTSJournal of Neurochemistry, 1979
- Effects of drugs on γ-aminobutyric acid receptors, uptake, release and synthesis in vitroBrain Research, 1978
- Europe's pollution politicsNature, 1977
- Parenteral Penicillin in Rats: An Experimental Model of Multifocal EpilepsyEpilepsia, 1976
- Gamma-aminobutyric acid (GABA) uptake by the developing mouse brain in vivoBrain Research, 1972
- THE COMPARATIVE EFFECTS OF VARIOUS HYDRA‐ZIDES ON γ‐AMINOBUTYRIC ACID AND ITS METABOLISMJournal of Neurochemistry, 1971