Effect of Carbon Blacks on Carcinogenic Compounds.

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Abstract
The mg of 20-methylcholanthrene adsorbed by 1 g of various carbon blacks are as follows: 111.8, NeoSpectra Mark II; 40.4, Peerless; 17.0, Micronex-deactivated; 10.9, Kosmos 60; 9.6, Micronex beads; 9.7, Philblack 0; and 8.3, Micronex. The amounts of 3,4-benzpyrene adsorbed is somewhat less; of p.dimethylaminoazo-benzene, much less. Differences in the amount adsorbed are related not only to the specific carcinogen but also to the total surface value of a carbon black. Administration of carbon black alone by feeding, painting and subcutaneous injection did not produce any benign or malignant tumor in 460 animals. The carcinogenicity of p-dimethyl-aminoazobenzene was almost completely inhibited by carbon black. Administration of carbon black-adsorbed 20-methylcholanthrene and 3,4-benzpyrene in combination with olive oil and acetone respectively inhibited carcinogenesis to a lesser degree since these carcinogens were partially eluted by the vehicles employed.