Catalysis by a Multiprotein IκB Kinase Complex
- 31 October 1997
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 278 (5339) , 818-819
- https://doi.org/10.1126/science.278.5339.818
Abstract
Many extracellular signals, tumor necrosis factor-a and interleukin-1 among them, transmit their signals to the genetic apparatus via the transcriptional activator, NF-kB. Maniatis summarizes what is known about this critical pathway and describes how two reports in this issue ( Mercurio et al. and Woronicz et al.) add to the story.This publication has 18 references indexed in Scilit:
- IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB ActivationScience, 1997
- The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB ActivationPublished by Elsevier ,1997
- Identification and Characterization of an IκB KinaseCell, 1997
- MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1Nature, 1997
- Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell DeathCell, 1996
- TRAF6 is a signal transducer for interleukin-1Nature, 1996
- THE NF-κB AND IκB PROTEINS: New Discoveries and InsightsAnnual Review of Immunology, 1996
- TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction PathwaysCell, 1996
- Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.Genes & Development, 1995
- The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and deathCell, 1994