The immunological properties of proteins treated with ββ′-dichlorodiethylsulphide (mustard gas) and ββ′-dichlorodiethylsulphone

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Abstract
[beta][beta]''-Dichlorodiethylsulphide (mustard gas), when allowed to act on horse-serum proteins at room temp., produces a change in the immunological properties of these proteins. These derivatives produce in the rabbit antibodies which are capable of reacting with mustard gas-treated rabbit serum. [beta][beta]''-Dichlorodiethylsulphone-treated horse-serum proteins produce antibodies which will react with sulphone-treated serum proteins, but not with the mustard gas-treated proteins. The possible chemical basis of this change in immunological properties may be an interaction between the mustard gas (or sulphone) and the free amino groups of the protein molecule.