Abstract
In 1924 I began a study of the blood in toxic goiter to ascertain, if possible, whether or not the data would be of any value in determining the prognosis of the disease. European authorities, notably Kocher,1and his American disciple, Crotti,2have laid considerable emphasis on the importance of the blood picture in hyperthyroidism. Little study of this subject has been made in our own country, with the exception of an important contribution by W. A. Plummer3in 1918, and general observations by Hertzler4and a few others. Plummer's report was made before the metabolic rate had come into general use. Hertzler states, in conclusion, that the observations to date are so variable that a further study is much desired. So far as I have been able to ascertain there has been no report of the coordinated blood picture and metabolic studies, nor any of

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