Comparison of cefpodoxime proxetil with cefaclor in the treatment of sinusitis
- 1 January 1990
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 26 (suppl E) , 87-91
- https://doi.org/10.1093/jac/26.suppl_e.87
Abstract
The efficacy and tolerance of cefpodoxime proxetil were compared with those of cetaclor in a multicentre, international, prospective, double-blind, placebocontrolled study in adult outpatients suffering from acute sinusitis. At the end of treatment, cefpodoxime proxetil was more effective than cefaclor, producing complete clinical cure in 84% of cases (102/122) vs 68% of cases (77/114) in the cefaclor group ( P = 0.01). The overall clinical efficacy (cure + improvement) was similar in the two groups with 95% (116/122) satisfactory responses in the cefpodoxime proxetil group and 93% (106/114) in the cefaclor group. Bacteriological response was similar with 95% eradication in the cefpodoxime proxetil group (55/58) vs 91% with cefaclor (63/69).Keywords
This publication has 0 references indexed in Scilit: