Chronic Sodium Chloride Toxicity in the Albino Rat I. Growth on a Purified Diet Containing Various Levels of Sodium Chloride

Publisher Website
Google Scholar
Abstract
Young male rats have been raised on a purified diet, containing 7 different levels of sodium chloride, and water ad libitum with the following results: Rats fed diets high (2.8 to 9.8%) and low (0.01%) in sodium chloride grew more slowly than did rats on a control ration (0.15% NaCl). High sodium chloride feeding caused polydipsia and polyuria but did not have a marked effect on appetite. A low-sodium diet caused mild anorexia. Edema developed during this first 20-week period in 10% of the rats fed diets containing from 7.0 to 9.8% of sodium chloride. The majority of the animals (89%) remained in excellent health throughout the 20 weeks.