Apert syndrome and palatal mucopolysaccharides

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Abstract
By means of histochemical techniques, six of seven patients with Apert syndrome were found to have a heavy deposit of acid mucopolysaccharides in the soft tissue of their characteristic palatal deformity, whereas only six of 15 patients with other palatal deformities (unassociated with the Apert syndrome) were found to have some acid mucopolysaccharide deposited in their palatal soft tissue. The mucopolysaccharides found in both groups were predominantly hyaluronic acid and to a lesser degree sulfated mucopolysaccharides. Examination of sections of skin from both groups of patients and the internal organs, postmortem, from one of the Apert patients failed to reveal the presence of mucopolysaccharides in these tissues.