Enzymatic cyclizations mediated by ultrasonically stimulated baker's yeast: synthesis of imidazo-fused heterocycles
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2755-2757
- https://doi.org/10.1039/p19900002755
Abstract
o-Cyanophenyl allyl carbamate (3), 3-allyl-3,4-dihydro-4-imino-2H-1,3-benzoxazine-2-thione (8a), and -quinazoline-2(1H)-thiones (8b–d) have been cyclized to 2,3-dihydro-2-methyl-5H-imidazo[1,2-c][1,3]benzoxazin-5-one (5), the corresponding 5-thione (9a), and 2,3-dihydro-2-methyl-5H-imidazo[1,2-c]quinazoline-5(6H)-thiones (9b–d), respectively, by ultrasonically stimulated baker's yeast. The effect of ultrasound on the yeast cells employed for the enzymatic reactions has been investigated. It is observed that ultrasonic pretreatment of yeast cells not only accelerates the cyclization process but improves the yields significantly.This publication has 1 reference indexed in Scilit:
- Enzymic cyclization of hydroxylated surrogate squalenoids with bakers' yeastJournal of the American Chemical Society, 1988