Evaluation of the Antiasthmatic Potential of Oxarbazole in Guinea Pigs
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 17 (6) , 323-329
- https://doi.org/10.1159/000136873
Abstract
Oxarbazole, 9-benzoyl-2,3,4,9,-tetrahydro-6-methoxy-1H-carbazole-3-carboxylic acid, inhibited bronchoconstriction induced by a crude SRS-A preparation or by bradykinin in dose-related manner in anesthetized guinea pigs. Oxarbazole was ineffective against bronchoconstriction induced by histamine, carbachol, serotonin, or PGF2α. Inhibition of bronchoconstriction induced by the crude SRS-A preparation by oxarbazole was unimpeded by the presence of β-adrenergic- or cholinergic-blocking agents, but it could be overcome by increased doses of the crude SRS-A preparation.Keywords
This publication has 3 references indexed in Scilit:
- Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acidsJournal of Medicinal Chemistry, 1977
- Antagonism of slow reacting substance in anaphylaxis (SRS-A) and other spasmogens on the guinea pig tracheal chain by hydratropic acids and their effects on anaphylaxisJournal of Medicinal Chemistry, 1975
- BRONCHOCONSTRICTOR ACTION AND ANTAGONISM OF A SLOW‐REACTING SUBSTANCE FROM ANAPHYLAXIS OF GUINEA‐PIG ISOLATED LUNGBritish Journal of Pharmacology and Chemotherapy, 1964