A n + 1 Strategy for Macrocyclization Based on Free-Radical Carbonylation
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (08) , 643-645
- https://doi.org/10.1055/s-1994-22958
Abstract
The synthesis of 10-17 membered 4-oxolactones 2 from alkyl iodides 1 having an acryloxy moiety at the termini, carbon monoxide, and TTMSS (or tin hydride) takes place cleanly in moderate to good yield under free radical conditions. Low concentrations of 1 (0.005-0.01 M) are favorable for both intermolecular trap of CO and intramolecular acyl radical addition to the C-C double bond.Keywords
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