Tissue carbon dioxide stores: magnitude of acute change in the dog

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Abstract
Carbon dioxide washout curves were determined in hyperventilated dogs. Direct measurement of mixed venous carbon dioxide tension allowed calculation of changes in whole-body CO2 stores. The average whole-body CO2 dissociation constant in ten studies was 3.73 ml/kg mm. The limiting factor in reaching a new steady-state value was represented by a slow compartment in the washout curve. The average rate constant for this compartment was 0.062 min–1. The slowest compartment in this analysis has a 98% change in 1 hr, therefore the experimentally determined whole-body dissociation constant should closely approximate actual changes in tissue CO2 stores, excluding bone and fat.