Comparison of Surgical Complications After Organ-Preservation Therapy in Patients With Stage III or IV Squamous Cell Head and Neck Cancer

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Abstract
COMBINATIONS of surgery and radiation therapy are standard treatments for patients with advanced local or regional squamous cell carcinoma of the head and neck.1 Adjuvant and neoadjuvant chemotherapy has been added to various multimodality approaches.1-7Concurrent chemotherapy and radiation therapy has also been proposed.8-10 Advantages of this approach include the independent antineoplastic activity of both treatments, the radiotherapeutic potentiation exerted by several chemotherapeutic agents, the possibility that systemic chemotherapy may decrease micrometastatic spread, and the relatively short duration of therapy.8