Lectin‐binding in premalignant lesions during submandibular gland carcinogenesis

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Abstract
Complex carbohydrates in premalignant lesions of mouse submandibular gland tumors were examined by the lectin‐peroxidase conjugate method. Peroxidase‐conjugated lectins of PNA, RCA‐1, DBA, SBA, UEA‐1 and WGA were used to detect specific sugar residues of complex carbohydrates in premalignant lesions during experimental carcinogenesis. Marked reduction of PNA and SBA bindings occurred in duct‐like structures and cystic lesions which were transformed from granular convoluted tubule cells. Premalignant lesions bound slightly to PNA, RCA‐1, DBA, SBA and WGA and manifested increased UEA‐1 binding. Squamous metaplastic epithelia of premalignant lesions manifested increased binding to PNA, RCA‐1 and SBA as compared to those of duct‐like structure and cystic epithelia.