Delivery Efficiency of Metered Dose Aerosols Given Via Endotracheal Tubes
Open Access
- 1 June 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 70 (6) , 1008-1010
- https://doi.org/10.1097/00000542-198906000-00021
Abstract
The authors studied the efficiency of delivery of the inhaled bronchodilator metaproterenol when delivered via an endotracheal tube (ETT) using a metered dose inhaler (MDI). They found that the percentage of drug exiting the ETT varied with tube size, ranging from 3.0 .+-. 1.9 for a 6.0 mm ETT to 6.5 .+-. 4.4 for a 9.0 mm ETT (mean .+-. SEM, P < 0.05). The efficiency of delivery was also affected by whether the MDI was activated before or after initiation of gas flow through the ETT, with activation into a flowing stream significantly more efficient. The authors conclude that an MDI can deliver a dose of drug to the trachea, but delivery efficiency is lower than reported for MDI delivery in spontaneously breathing patients.This publication has 0 references indexed in Scilit: