Decrease in cerebral inositols in rats and humans
- 1 October 1993
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 295 (1) , 15-18
- https://doi.org/10.1042/bj2950015
Abstract
Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.Keywords
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