Pharmacokinetics of Rifampicin and Desacetylrifampicin in Tuberculous Patients After Different Rates of Infusion

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Abstract
Four rates of rifampicin infusion ranging from 3.3-15 mg/min in 12 tuberculous patients were studied. Blood samples (10) were drawn during infusion and 8 h later. Urine samples were collected in 6 fractions over 24 h. Rifampicin and desacetylrifampicin were measured by high-pressure liquid chromatography. The maximum plasma concentrations increase linearly for each dose with the rate of infusion; the amounts excreted in the urine are highly dependent on the administered dose. Simulation of plasma concentrations after different dosage regimens shows that a double rate of infusion 20 mg min-1 during 1 h and then 200 mg h-1 allows plasma concentrations to be quickly reached and maintained at a 20 mg l-1 level, far higher than the minimum inhibitory concentrations of most bacteria.

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