DECREASED EXCRETION OF CORTISONE METABOLITES IMMEDIATELY FOLLOWING ASCORBIC ACID TREATMENT

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Abstract
IN THE course of studying the role of ascorbic acid in adrenal cortex function it was observed that the vitamin is capable of prolonging the hematologic actions of exogenous and of endogenous cortical hormones (Bacchus, Altszuler, Heiffer, 1952a, b). The data were interpreted as indicating that the ascorbic acid in some manner may be responsible for either a diminished excretion or a diminished inactivation of these hormones. At any rate, detectable amounts of the hormones persisted in the animals which received simultaneous ascorbic acid treatment. The present paper reports data which indicate that the excretion of 17-ketosteroids in the first 24-hour urine sample following cortisone is diminished by ascorbic acid treatment. This diminished excretion of the metabolites corresponds very well with the observed period of prolongation of hematologic effects noted above. MATERIALS AND METHODS Female adrenalectomized Wistar rats were the animals of choice in this experiment. It is generally accepted that the chief source of 17-ketosteroids in the female is the adrenal cortex (Heard, 1948; Selye, 1952).

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