Effect of Splenectomy on Antibody Formation in Cortisone Treated Rats

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Abstract
Spienectomy, performed 1 day after an intraperitoneal injection of a large dose of sheep erythrocytes, reduced the initial part of the hemolysin response, but did not significantly affect a later part. The antibody-reducing effect of cortisone was significantly greater in splenectomized than in sham operated rats.