PRELIMINARY COMMUNICATION - TREATMENT OF PRIMARY BRAIN-TUMORS RECURRENT AFTER IRRADIATION WITH AZIRIDINYLBENZOQUINONE (AZQ - NSC-182986)

  • 1 January 1983
    • journal article
    • research article
    • Vol. 6  (5) , 577-578
Abstract
Patients (29) with primary brain tumors recurrent or progressive after cerebral irradiation were treated with AZO [aziridinylbenzoquinone]. Twenty of the 29 patients had also failed prior chemotherapy. CT [computed tomography] scan-documented tumor regressions were noted in 17.2% (5/29) and ranged from 15.0% (3/20) in patients with prior chemotherapy to 22.2 (2/9) in patients without prior chemotherapy. Myelosuppression was the only significant toxicity noted. AZQ is worthy of further studies in patients with primary brain tumors.

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