BREAST CANCER CYTOGENETICS AND BEYOND

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Abstract
It is hypothesized that cancers arise as a result of genetic or chromosomal alteration. Evidence for this provided by the leukaemias and lymphomas in which cytogenetic studies are of established value in diagnosis, classification and follow‐up. In contrast, the cytogenetic study of all solid turnours, including breast carcinoma, is in its infancy.However, cytogenetic studies indicate that clonal structural alterations do occur, affecting several loci on a number of chromosomes. Molecular studies provide further evidence of recurring chromosomal breakpoints breast cancer. This paper reviews the chromosomal rearrangements observed to date and discusses their relevance to the biology of breast cancer.