MUTAGENIC POTENTIAL OF ANTICONVULSANT DIPHYENYLHYDANTOIN (DPH) ON HUMAN-LYMPHOCYTES INVITRO

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 7  (3) , 109-112
Abstract
Diphenylhydantoin (DPH)-treated human peripheral blood cultures were examined for sister chromatid exchange (SCE) frequency and mitotic index. A significantly enhanced SCE frequency in DPH-treated cultures was observed at a 15 .mu.g/ml concentration (10-20 .mu.g/ml DPH therapeutic range) and above. These results suggest an enhanced SCE response of lymphocytes in the therapeutic blood level of DPH. A significant linear fall in mitotic index was observed with increasing DPH concentrations. Even in therapeutic doses DPH possibly affects nucleic acid metabolism. [Diphenylhydantoin is known to cause congenital malformations.].

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