Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids

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Abstract
Rabbit aorta contracting substance-releasing factor (RCS-RF) was found in perfusates from guinea pig lungs during anaphylaxis. It was identified as a small peptide which released arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and and thromboxanes and causing bronchoconstriction. Anti-inflammatory steroids blocked the release of arachidonate by RCS-RF. In this activity their relative potency was very similar to their relative anti-inflammatory potency, suggesting that the 2 actions may be related.