Transforming Growth Factor Beta (TGFβ) Is Produced by and Influences the Proliferative Response of Xenopus laevis Lymphocytes
Open Access
- 1 January 1993
- journal article
- research article
- Published by Hindawi Limited in Developmental Immunology
- Vol. 3 (3) , 223-230
- https://doi.org/10.1155/1993/63626
Abstract
Both TGF/β2 and 5 have been described in the South African clawed frog Xenopus laevis and have been cloned from the tadpole-derived fibroblast cell line, XTC. Because TGFβ has such a profound inhibitory effect on the mammalian immune system, this study was performed to determine whether TGFβ: (a) has any in vitro effects on the growth of Xenopus lymphoblasts, and (b) is produced by mitogen-activated Xenopus lymphocytes.Keywords
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