Crude coal tar plus near ultraviolet light suppresses DNA synthesis in epidermis
- 1 January 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 114 (1) , 43-45
- https://doi.org/10.1001/archderm.114.1.43
Abstract
Crude coal tar and a refined product, when they are combined with near UV light (UVA, 320-400 nm), depress DNA synthesis in vivo in normal and proliferating skin of the hairless mouse. UVA light alone does not interfere with DNA synthesis, but coal tar without UVA does have an inhibitory effect on DNA synthesis of normal skin. This effect of coal tar without UVA is not as great as the effect of the combination of UVA and coal tar. Between 0.9 and 1.6 J/cm2 of UVA are required for its biologic effect on DNA synthesis in coal-tar-treated skin. [Coal tar is used to treat human psoriasis and eczema.].This publication has 1 reference indexed in Scilit:
- Clinical and histological study of coal tar phototoxicity in humansArchives of Dermatology, 1977