Pulmonary Embolism in a Homocystinuric Patient during Treatment with Dipyridamole and Acetylsalicylic Acid

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Abstract
To the Editor: In 1974 Harker and his associates1 reported that four patients with homocystinemia due to cystathionine synthase deficiency manifested a shortened platelet survival in vivo and that this platelet survival could be increased to normal by treatment with dipyridamole and aspirin. Treatment with 100 mg of dipyridamole and 1 g of acetylsalicylic acid daily appeared to be associated with an abolition of subsequent vascular occlusive or thromboembolic events in their patients. Our own studies of six homocystinemic patients2 failed to confirm the shortening of platelet survival in this disorder. However, we and some other physicians caring for patients . . .

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