LEUKO-ENCEPHALOPATHY WITH CROSSED CEREBRO-CEREBELLAR HEMIATROPHY
- 1 December 1963
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 39 (4) , 343-355
- https://doi.org/10.1111/j.1600-0404.1963.tb05335.x
Abstract
A woman without known familial predisposition developed leukoencephalopathy. The disease set in as optic neuritis at the age of 29. The symptoms were progressing disturbances of gait, dementia, and convulsions as well as hemiparesis. Death occurred at the age of 45. Autopsy revealed leukoencephalopathy which was interpreted as a transitional variety of disseminated sclerosis and sudanophilic diffuse sclerosis (Schilder). The process predominated in one cerebral hemisphere and was accompanied by cerebellar atrophy, most marked in the neocerebellar parts of the contralateral cerebellar hemisphere. A quantitative chemical analysis of the lipid fractions in the brain tissue was carried out. The relationship between the leukoencephalopathy and the cerebellar and cortical atrophy is discussed.Keywords
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