A [2 + 2] photo-adduct of 8-methoxypsoralen and thymine: X-ray crystal structure; a model for the reaction of psoralens with DNA in the phototherapy of psoriasis
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 22-23
- https://doi.org/10.1039/c39820000022
Abstract
Ultaviolet irradiation of a mixture of 8-methoxypsoralen and thymine in an ice-methanol matrix in the presence of benzopenone affords a [2 + 2] adduct which is shown by X-ray crystallography to result from cis-bonding of the 4′- and 5′-(furan) positions of the 8-methoxypsoralen to, respectively, the 5- and 6-positions of the thymine.Keywords
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