Multicentric Independent Development of Hepatocellular Carcinoma Revealed by Analysis of Hepatitis B Virus Integration Pattern
- 1 December 1989
- journal article
- case report
- Published by Wolters Kluwer Health in The American Journal of Surgical Pathology
- Vol. 13 (12) , 1064-1067
- https://doi.org/10.1097/00000478-198912000-00009
Abstract
Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological finding is consistent with the multistep and independent development of HCC in each site of the liver.Keywords
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