Cooperation of Myb and Myc proteins in T cell lymphomagenesis
Open Access
- 17 June 1999
- journal article
- research article
- Published by Springer Nature in Oncogene
- Vol. 18 (24) , 3643-3647
- https://doi.org/10.1038/sj.onc.1202956
Abstract
The v-Myb oncogene causes late onset T cell lymphomas when expressed in the T cell lineage of transgenic mice. In order to define the cellular mutations cooperating with v-Myb to cause lymphomas, we have infected v-Myb transgenic mice with Moloney murine leukemia virus (M-MuLV). Tumor formation is significantly accelerated from a mean age of onset of 60 weeks in uninfected vMyb transgenics to 13 weeks in infected vMyb transgenics. We studied the loci into which the M-MuLV had inserted, and found that in 73% of animals, either the c-myc or the N-myc genes had been disrupted and deregulated. Therefore, v-myb and c-myb can cooperate to induce T cell lymphomas.Keywords
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