Effects of Fenwal 4C2423 Transfusion Microfilter on Microaggregates and Other Constituents of Stored Blood

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Abstract
The effects of a new micropore transfusion filter (Fenwal 4C2423) on stored whole [human] blood were examined. Five filters were preloaded by passage of 2 units of outdated type specific bank blood, and the effects of filtration on a 3rd unit, consisting of 21 day old blood, flowing under 150 mmHg pressure, were measured. Filtration did not significantly alter red blood cell count, total hemoglobin, red blood cell fragility, plasma sodium, potassium, albumin or globulin. Some platelets and white blood cells were removed and a small amount of hemolysis of erythrocytes (< 0.1%) was observed. Removal of microaggregates, assessed by Coulter counting, screen filtration pressure, total screen proteins, wet and dry weights of material retained, and scanning electron microscopy, was excellent over the entire range of particle size. Comparison of the Bentley PFS-127, Fenwal 4C2417, Johnson and Johnson Intersept, Pall Ultipore and Swank IL200 filters showed that the Fenwal 4C2423 was both a significant improvement over the previous Fenwal design and comparable to the most efficient of these filters for the removal of microaggregates during massive blood transfusion and for the blood flow rates obtained.

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