THE EXTERNAL SECRETORY FUNCTION OF THE HUMAN PANCREAS
- 1 May 1938
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 61 (5) , 739-754
- https://doi.org/10.1001/archinte.1938.00180100049006
Abstract
The earliest basic knowledge of the physiology of the external function of the pancreas came largely as a result of the pioneer studies of two eminent experimental physiologists, Claude Bernard1 and Ivan Pavlov.2 The former, in 1856, showed that pancreatic juice is highly essential to digestion; the latter, in 1902, demonstrated the existence of pancreatic enzymes. In the same year Bayliss and Starling3 investigated the factors concerned in the secretory stimulus of the pancreas and assigned the important role to a humoral mechanism which they named secretin. Many valuable contributions to the physiology of the pancreas have been made during the past thirty years, and McClure4 in a recent paper has enumerated as follows the important physiologic facts which are now firmly established: 1. Stimulation of the external secretion of the pancreas is of humoral origin, but the exact mechanism remains undetermined. 2. The ingestion ofThis publication has 3 references indexed in Scilit:
- A STUDY OF EXTERNAL PANCREATIC SECRETION IN MANJournal of Clinical Investigation, 1936
- ON THE COLLECTION OF THE ENTIRE EXTERNAL SECRETION OF THE PANCREAS UNDER STERILE CONDITIONS AND THE FATAL EFFECT OF TOTAL LOSS OF PANCREATIC JUICEThe Journal of Experimental Medicine, 1927
- CONTRIBUTIONS TO THE PHYSIOLOGY OF THE PANCREASAmerican Journal of Physiology-Legacy Content, 1926