In VitroSusceptibility of Pathogenic Staphylococci to Seven Antibiotics: (Penicillin, Streptomycin, Bacitracin, Polymyxin, Aerosporin, Aureomycin and Chloromycetin)

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Abstract
Penicillin was the most active of these antibiotics against about 2/3 of the strains tested but there were wider variations in the susceptibility of the different strains to penicillin than to any of the other antibiotics studied. Aureomycin was the most active of the other 6 antibiotics against almost all of the strains. Chloromycetin ranked next and was appreciably less active. Streptomycin was more active than the latter against a few of the strains but was less effective against most of them. Bacitracin was appreciably less active than streptomycin and aerosporin was inhibitory only in high concns. while polymyxin was ineffective in the highest concns. used. Strains of staphylococci isolated and tested before 1946 were inhibited by significantly lower concns. of penicillin than those required for strains isolated subsequently.

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