Dose-Response Relationship of a Topical Nasal Decongestant: Phenylpropanolamine
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 98 (5-6) , 543-547
- https://doi.org/10.3109/00016488409107595
Abstract
By means of anterior rhinomanometry, the decongestant effect of topically applied phenylpropanolamine (PPA) was evaluated in 40 patients with nasal obstruction. A dose-response relation was obtained for 0.5, 2.5 and 5.0% PPA solution, with the maximum effect (40% decongestion) found with the 2.5% solution. The decongestant effect was comparable to that induced by physical exercise (50% decongestion). It is concluded that PPA nose-drops are effective and offer an attractive alternative to some of the commonly used nasal decongestants.Keywords
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