Glycosidation of Chlormadinol Acetate Alters its Actions on Na+/K+-Transporting ATPase and Cardiac Contractility: A Contribution to the Endogenous Digitalis Problem
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Enzyme Inhibition
- Vol. 2 (1) , 31-36
- https://doi.org/10.3109/14756368709030354
Abstract
Compared to the progesterone derivative chlormadinol acetate 1, the arabinofuranoside 2, rhamnoside 3 and glucoside 4 of 1 are less potent in the Na/K-ATPase assay, but evoke, contrary to 1, positive inotropy in vivo. In anaesthetized cats the circulation effects of 2 and 3 appear to be more favourable than those of the digitalis glycoside digitoxin. Hence, the progestin 1 is transformed through glycosidation into an interesting cardioactive steroid.Keywords
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