Immunological Partial Identity and in vitro Inhibitory Effect of Two Major Timothy Pollen Allergens to Whole Pollen Extract of Four Grasses
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 57 (4) , 379-383
- https://doi.org/10.1159/000232128
Abstract
Crossed immunoelectrophoresis in various modifications has directly revealed the immunological partial identity between isolated major allergens of timothy pollen (antigens 19 and 25) and the corresponding pollen allergens of false oat, orchard and rye grass, using rabbit antibodies raised against all four grasses. The inhibitory effects of antigens 19 and 25 relative to those of whole pollen extracts have been determined by means of RAST, inhibiting serum pools from selected grass-pollen-allergic patients and using insolubilized whole pollen extracts from the four grasses as allergosorbents. The inhibitory effects of antigens 19 and 25 were determined to be 97, 91, 92 and 73% of those of whole extracts of timothy, false oat, orchard and rye grass, respectively.Keywords
This publication has 2 references indexed in Scilit:
- Isolation and Partial Characterization of Three Allergens of Timothy PollenAllergy, 1978
- The cross-reactivity of IgE antibodies with pollen allergensJournal of Allergy and Clinical Immunology, 1976