Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis. I. Taxonomy, Fermentation, Isolation and Antimicrobial Activities.
Open Access
- 1 January 1997
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 50 (11) , 900-905
- https://doi.org/10.7164/antibiotics.50.900
Abstract
A new structural class of the antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these antibiotics showed improvement of collagen induced arthritis in vivo.Keywords
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