New AccI Polymorphism in the Follicle-Stimulating Hormone Beta-Subunit Gene andIts Prevalence in Three Southeast AsianPopulations
- 31 May 1999
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 49 (3) , 181-182
- https://doi.org/10.1159/000022869
Abstract
A thymine-cytosine substitution was identified in exon 3 (codon 76, TAT to TAC) of the human follicle-stimulating hormone (FSH) β-subunit gene. The nucleotide change led to creation of an AccI digestion site. The frequencies of the A allele (with AccI site) in Chinese (n = 201), Malays (n = 168) and Indians (n = 132) were 0.358, 0.333 and 0.402, respectively. The new FSH β-subunit marker may be useful in gene tracking and association studies.Keywords
This publication has 2 references indexed in Scilit:
- Molecular Variants of Luteinizing Hormone in Three Populations of Southeast AsiaHuman Heredity, 1998
- Glycoprotein Hormones: Structure and FunctionAnnual Review of Biochemistry, 1981