Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues

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Abstract
The synthesis and some pharmacological effects of 16 3-aryl analogs of butaclamol, a new antipsychotic drug, are described. The animal [rats] models were predictive of neuroleptic activity as well as side effects commonly associated with neuroleptic therapy. The results indicate that the 3-substituent plays a critical role with regard to the potency of the compounds as well as to their tendencies to induce extrapyramidal side effects and/or hypotension.

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