Role of the Preoptic Area in the Neuroendocrine Regulation of Reproduction: An Analysis of Functional Preoptic Homografts
- 1 December 1986
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 474 (1) , 53-63
- https://doi.org/10.1111/j.1749-6632.1986.tb27998.x
Abstract
In conclusion, POA grafts that contain GnRH cell bodies are capable of correcting many of the reproductive deficiencies that are associated with a genetic failure to produce GnRH. The previously infertile animals exhibit steroidogenesis and gametogenesis. Ovulations associated with mating suggest that the grafted GnRH cells are responding to some environmental cues and may be under some regulation by the host brain. Although the grafts contain tissue that may have sexually dimorphic characteristics, the studies with the hpg mice have not yet revealed any effects of the grafts that could be related to the sex of the donor.Keywords
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