Three Kinds of Tumour‐Unique Surface Molecules on a Human T‐Cell Chronic Lymphocytic Leukaemia (T‐CLL) Detected by Monoclonal Antibodies

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Abstract
Mouse monoclonai antibodies recognizing cell surface molecules on tumour cells from a patient with a T‐cetl chronic lymphatic lcukacmia (T‐CLL) have been produced. Three different types of idiotype‐like cell Surface structures were identified. One molecule had a relative molecular weight (Mr) of 90,000 under non‐reduced conditions and of 42,000 upon reduction, which corresponds well to the T‐cell receptor for antigen (Tt). The two other molecules, which also behaved like unique tumour markers, have not previously been described, to our knowledge. One molecule wasa monomer with an Mr, of 74,000–80,000 when non‐reduced and 80,000 upon reduction. The other idiotypic molecule was a dimer with a non‐reduced Mr of 74,000–80,000, and 38,000 after reduction.